Table 4.
Thickness measurements made at the macular level at baseline and at 3 and 12 months of follow up in patients with obstructive sleep apnea undergoing continuous positive airway pressure treatment.
| Baseline | 3 Months | 12 Months | P* Raw | P** Adjusted (1) (2) (3) |
|
|---|---|---|---|---|---|
| TR | |||||
| F | 284.82 (±20.93) | 286.61 (±21.51) | 286.37 (±20.96) | 0.035 |
0.010 0.134 0.999 |
| IIM | 342.90 (±17.56) | 345.10 (±18.46) | 344.75 (±18.05) | <0.001 |
<0.001 <0.001 0.999 |
| IOM | 289.10 (±16.79) | 290.55 (±17.42) | 290.06 (±17.37) | 0.003 |
0.007 0.081 0.659 |
| TIM | 332.82 (±16.20) | 333.53 (±20.05) | 335.29 (±16.09) | 0.091 | 0.999 <0.001 0.496 |
| TOM | 285.57 (±21.00) | 286.94 (±17.27) | 284.80 (±15.97) | 0.003 |
<0.001 0.108 0.120 |
| SIM | 346.51 (±17.68) | 348.25 (±18.53) | 347.47 (±18.08) | 0.001 |
0.001 0.139 0.245 |
| SOM | 297.71 (±17.20) | 299.04 (±18.53) | 298.06 (±17.41) | 0.018 | 0.057 0.999 0.079 |
| NIM | 348.31 (±16.48) | 350.92 (±18.33) | 350.98 (±17.66) | 0.016 | 0.056 0.062 0.999 |
| NOM | 316.53 (±20.07) | 317.55 (±18.80) | 315.94 (±18.75) | 0.199 | NA |
| RGCL | |||||
| F | 18.85 (±6.22) | 18.60 (±6.04) | 18.40 (±6.05) | 0.232 | NA |
| IIM | 53.35 (±5.35) | 53.54 (±5.99) | 53.40 (±5.77) | 0.787 | NA |
| IOM | 33.44 (±4.43) | 33.31 (±4.31) | 33.58 (±3.89) | 0.107 | NA |
| TIM | 49.48 (±5.91) | 49.29 (±6.46) | 49.52 (±6.04) | 0.650 | NA |
| TOM | 36.17 (±4,74) | 36.23 (±5.07) | 36.06 (±4.75) | 0.796 | NA |
| SIM | 53.79 (±5.26) | 54.12 (±5.61) | 54.63 (±5.86) | <0.001 | 0.312 <0.001 0.048 |
| SOM | 34.98 (±3.98) | 35.10 (±4.02) | 35.15 (±4.07) | 0.623 | NA |
| NIM | 52.75 (±6.12) | 52.40 (±6.87) | 52.71 (±6.61) | 0.712 | NA |
| NOM | 38.13 (±4.58) | 38.46 (±5.09) | 38.62 (±5.41) | 0.173 | NA |
| IPL | |||||
| F | 23.77 (±4.36) | 23.79 (±4.46) | 23.75 (±4.15) | 0.988 | NA |
| IIM | 41.92 (±4.06) | 42.29 (±4.04) | 42.37 (±4.30) | 0.161 | NA |
| IOM | 27.02 (±3.24) | 27.23 (±3.40) | 27.04 (±3.15) | 0.375 | NA |
| TIM | 42.40 (±3.99) | 43.25 (±4.03) | 43.10 (±4.04) | 0.004 |
0.002 0.056 0.999 |
| TOM | 32.67 (±3.44) | 33.02 (±3.34) | 32.81 (±3.38) | 0.107 | NA |
| SIM | 42.48 (±3.76) | 42.85 (±3.56) | 42.52 (±4.27) | 0.261 | NA |
| SOM | 28.58 (±3.24) | 28.77 (±3.42) | 28.77 (±3.31) | 0.281 | NA |
| NIM | 43.46 (±3.88) | 43.77 (±4.00) | 44.02 (±3.81) | 0.079 | 0.061 0.046 0.999 |
| NOM | 29.33 (±3.27) | 29.54 (±3.23) | 29.31 (±3.31) | 0.226 | NA |
| PL | |||||
| F | 87.85 (±4.33) | 87.71 (±4.92) | 87.50 (±3.80) | 0.650 | NA |
| IIM | 79.08 (±2.70) | 79.52 (±3.05) | 78.60 (±4.90) | 0.146 | NA |
| IOM | 76.81 (±2.23) | 77.08 (±2.19) | 75.92 (±5.09) | 0.166 | NA |
| TIM | 80.08 (±2.91) | 80.33 (±2.87) | 79.69 (±3.03) | 0.105 | NA |
| TOM | 77.15 (±2.38) | 77.37 (±2.43) | 76.60 (±4.12) | 0.466 | NA |
| SIM | 80.25 (±2.81) | 80.17 (±2.86) | 79.88 (±2.72) | 0.847 | NA |
| SOM | 78.52 (±2.81) | 78.65 (±2.56) | 78.06 (±3.23) | 0.178 | NA |
| NIM | 80.98 (±3.03) | 81.62 (±3.19) | 80.98 (±3.37) | 0.130 | NA |
| NOM | 77.94 (±2.51) | 78.31 (±2.38) | 77.65 (±4.41) | 0.318 | NA |
Data expressed as the mean (±standard deviation). P* raw: significance level obtained by repeated measures ANOVA or Friedman test (according to normality of data distribution). P** adjusted: adjusted significance level obtained through post-hoc tests for multiple comparisons: Bonferroni or Wilcoxon (according to normality of data distribution). (1) Baseline vs. 3 months. (2) Baseline vs. 12 months. (3) 3 months vs. 12 months. NA: Post-hoc test not applicable for P* greater than 0.1. Values in bold indicate p < 0.05. TR = total retinal, F = fovea, IIM = inferior inner macula, IOM = inferior outer macula, TIM = temporal inner macula, TOM = temporal outer macula, SIM = superior inner macula, SOM = superior outer macula, NIM = nasal inner macula, NOM = nasal outer macula, RGCL = retinal ganglion cell layer, IPL = inner plexiform layer, PL = photoreceptor layer.