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. 2022 Oct 17;132(20):e158346. doi: 10.1172/JCI158346

Figure 4. l-kynurenine and downstream metabolites are upregulated during pregnancy in sham-treated but not UNx mice.

Figure 4

(A) Heatmap of metabolite changes in control and UNx mice in the NP state and at GD18, including changes in l-kynurenine (arrow). Plasma samples corresponding to the NP state were drawn 14 days after sham or uninephrectomy surgery. (B) Schematic of the l-tryptophan/l-kynurenine pathway. Levels of l-kynurenine (C), 3-hydroxy-DL-kynurenine (D), and 3-hydroxyanthranilic acid (E) in the NP state and at GD18 in sham-operated and UNx mice. Results are shown as the normalized peak intensities (arbitrary units) from the metabolite profiling studies. For each of the metabolites, the individual values, mean, and SD are shown. n = 4 per group. *P < 0.05, by 1-way ANOVA with Tukey’s test for multiple comparisons. (F) Quantification of placental Ido1 mRNA expression in sham and UNx mice at GD18. Data are presented as the mean ± SD. n = 4 per group. *P < 0.05 for UNx versus sham mice, by unpaired, 2-tailed Student’s t test.