FIGURE 1.

The work flow of each type of methods Figure 1 illustrates main three categories described in this article: (A) scoring function-based methods (B) machine learning-based methods and (C) consensus-based methods. The key steps for each type of methods are depicted in the diagram. Scoring function-based methods in (A), we use ANCHOR work flow to represent how scoring function works. Machine learning-based methods perform the prediction using various types of machine learning models like SVM and Neural Network based on features extracted from different perspectives. Consensus-based methods can predict IDP binding site by weighting different prediction models and combining them optimally. The final results show in (A) was processed by (Mészáros et al., 2018). The final results show in (B) was processed by (Malhis et al., 2016), The final results show in (C) was processed by (Barik et al., 2020).