TABLE 1.

Common features of intrinsically disordered protein-protein interaction sites predictors.

Categories	Features	Tools to calculate	References of the tools
Amino acid composition	Amino acid composition	$\mathit{composition}\left(\mathit{i}\right)=\frac{{\mathit{n}}_{\mathit{i}}}{\mathit{N}}$	Wang et al. (2017)
Predicted structural features	Secondary structure	PSIPRED & GOR-I & SPIDER2 & SPOT-1D & Porte	Garnier et al. (1996); Jones, (1999); Pollastri and McLysaght, (2004); Heffernan et al. (2015); Hanson et al. (2018)
	Accessible surface area	SPIDER2 & SPOT-1D & EDTSurf	Xu and Zhang, (2009); Heffernan et al. (2015); Hanson et al. (2018)
	Backbone angle	SPIDER2 & SPOT-1D	Heffernan et al. (2015); Hanson et al. (2018)
	Hemispheric exposure	SPIDER2 & SPOT-1D	Heffernan et al. (2015); Hanson et al. (2018)
	Contact numbers	SPIDER2 & SPOT-1D	Heffernan et al. (2015); Hanson et al. (2018)
	B-factor	ProDy & PROFbval	Schlessinger et al. (2006); Wong and Gsponer, (2019b)
	Structural motifs	BRNN	Mooney et al. (2006)
Disorder scores	Disorder scores	IUPred & Espritz & VSL2 & DISOPRED2 & DISOclust & MFDp	Ward et al. (2004); Dosztanyi et al. (2005); Peng et al. (2006); McGuffin, (2008); Mizianty et al. (2010); Walsh et al. (2011)
Physicochemical properties	Physicochemical properties	AAindex database	Kawashima et al. (2007)
Evolutionary information	Position-Specific Scoring Matrix	PSI-BLAST	Altschul, (1997)
	Bigram feature
	Hidden Markov Model	HHblits	Remmert et al. (2011)
	Shannon entropy
Other features	The length and location of IDR
	Sequence complexity	SEG algorithm	Peng and Kurgan, (2015)