(a) Difference in IgM optical densities of positive and
negative (P − N) wells for each infant by week after measles
vaccination. The larger dashed line represents the 50th percentile for
each week (a week was defined as a multiple of 7 ± 3 days; e.g.,
week 2 = 11 to 17). The horizontal dashed line represents the
cutoff P − N value of 0.10, which was used in combination with
the P/N ratio to determine whether the specimen was considered IgM
positive, IgM borderline, or IgM negative. (b) Difference in IgG
optical densities of P − N wells for each infant by week after
vaccination. As in panel a, the larger dashed line represents the 50th
percentile for each week, and the horizontal dashed line represents the
cutoff P − N value of 0.09. Both graphs include only data for
infants who were both IgM and IgG negative before vaccination.