Table 3.
Logistic regression for kidney function pattern and associated inpatient mortality among those with ACLF
| Univariable |
Multivariable |
|||||
|---|---|---|---|---|---|---|
| OR | 95% CI | p-value | OR | 95% CI | p value | |
| Kidney diagnosis | ||||||
| Normal | 1.39 | 1.32–1.45 | < 0.001 | 0.58 | 0.51–0.64 | < 0.001 |
| AKI | 3.33 | 3.20–3.47 | < 0.001 | 1.21 | 1.08–1.33 | < 0.001 |
| CKD | – | – | – | – | – | – |
| AKI on CKD | 2.11 | 2.02–2.22 | < 0.001 | 1.03 | 0.92–1.16 | 0.52 |
| Age per year | 1.01 | 1.01–1.01 | < 0.001 | 1.01 | 1.01–1.01 | < 0.001 |
| Female sex | 1.00 | 0.98–1.03 | 0.77 | |||
| Race | ||||||
| Caucasian | – | – | – | – | – | – |
| African-American | 1.12 | 1.07–1.67 | < 0.001 | 1.22 | 1.16–1.28 | < 0.001 |
| Hispanic | 1.01 | 0.97–1.06 | 0.50 | 1.20 | 1.15–1.25 | < 0.001 |
| Asian | 1.18 | 1.08–1.28 | < 0.001 | 1.15 | 1.05–1.26 | < 0.001 |
| Other | 1.00 | 0.96–1.04 | 0.91 | 1.05 | 1.01–1.10 | 0.03 |
| Hepatitis C | 1.54 | 1.48–1.60 | < 0.001 | 1.29 | 1.23–1.34 | < 0.001 |
| EtOH-related | 0.99 | 0.96–1.02 | 0.53 | |||
| Diabetes mellitus | 0.54 | 0.52–0.56 | < 0.001 | 0.79 | 0.76–0.82 | < 0.001 |
| Hospital location | ||||||
| Metropolitan city center | – | – | – | |||
| Metropolitan county | 0.95 | 0.91–0.98 | 0.003 | |||
| Large county | 0.88 | 0.84–0.91 | < 0.001 | |||
| Medium county | 0.87 | 0.83–0.92 | < 0.001 | |||
| Micropolitan county | 0.88 | 0.84–0.93 | < 0.001 | |||
| Other | 0.87 | 0.81–0.92 | < 0.001 | |||
| Infectious status | ||||||
| None | – | – | – | – | – | – |
| Infection | 0.87 | 0.82–0.91 | < 0.001 | 0.80 | 0.75–0.84 | < 0.001 |
| Sepsis | 2.42 | 2.34–2.50 | < 0.001 | 1.32 | 1.26–1.37 | < 0.001 |
| Mechanical ventilation | 3.10 | 2.99–3.21 | < 0.001 | 2.70 | 2.59–2.81 | < 0.001 |
| Shock | 2.59 | 2.52–2.67 | < 0.001 | 1.88 | 1.81–1.95 | < 0.001 |
| Year of admission | ||||||
| 2007–2008 | – | – | – | – | – | – |
| 2009–2010 | 0.91 | 0.88–0.95 | < 0.001 | 0.84 | 0.80–0.88 | < 0.001 |
| 2011–2012 | 0.81 | 0.78–0.84 | < 0.001 | 0.73 | 0.70–0.76 | < 0.001 |
| 2013–2014 | 0.76 | 0.73–0.79 | < 0.001 | 0.66 | 0.63–0.69 | < 0.001 |
| Decompensated cirrhosis | 0.56 | 0.53–0.58 | < 0.001 | 0.79 | 0.75–0.83 | < 0.001 |
| RRT | 0.76 | 0.74–0.78 | < 0.001 | 0.72 | 0.64–0.80 | < 0.001 |
| Kidney diagnosis and dialysis# | ||||||
| Normal | – | – | – | – | – | – |
| AKI | 3.08 | 2.74–3.45 | < 0.001 | 2.10 | 1.87–2.37 | < 0.001 |
| CKD | Ref | Ref | Ref | Ref | Ref | Ref |
| AKI on CKD | 1.85 | 1.63–2.09 | < 0.001 | 1.47 | 1.27–1.65 | < 0.001 |
AKI acute kidney injury, CKD chronic kidney disease, AKI on CKD acute kidney injury on chronic kidney disease, EtOH alcohol-related disease, RRT renal replacement therapy
#
This is the interaction term between variables