. 2022 Aug 29;54(5):981–990. [Article in Chinese] doi: 10.19723/j.issn.1671-167X.2022.05.027

表 2.

63例副肿瘤性天疱疮合并实体肿瘤患者总生存的单因素分析

Univariate analyses of overall survival in 63 patients with solid tumors complicated with paraneoplastic pemphigus

Items	Survival rate/%		Log-rank		Cox univariate analysis
Items	1 year	5 years	χ ²	P value	HR (95%CI)	P value
a, entered into the Cox model as continuous variable; b, the number of events is less than 5, so the Kaplan-Meier survival analysis were not performed; * P < 0.1. BMI, body mass index; PNP, paraneoplastic pemphigus; CD, Castleman disease; PDAI, pemphigus disease area index; DSG, desmoglein; BP, bullous pemphigoid; BO, bronchiolitis obliterans; ICU, intensive care unit; WBC, white blood cell; PaCO₂, partial pressure of carbon dioxide in artery; OI, oxygenation index; Hgb, hemoglobin; APACHE, acute physiology and chronic health evaluation; SOFA, sequential organ failure assessment; PCT, procalcitonin.
Baseline characteristics
Age/years			4.145	0.042^*
≤40	79.6	69.2			1
>40	69.7	41.1			2.23 (1.00-5.40)	0.051^*
Gender			0.344	0.558
Female	68.4	52.5			1
Male	79.2	59.9			0.79 (0.35-1.78)	0.563
Preoperative weight loss			9.567	0.002^*
≤5 kg	95.5	76.5			1
>5 kg	63.0	43.7			4.77 (1.60-14.2)	0.005^*
BMI/(kg/m²)^a					1.02 (0.90-1.15)	0.815
Preoperative comorbidities^b					1.14 (0.88-1.53)	0.695
Smoking^b					1.65 (0.71-2.40)	0.237
Preoperative data of PNP
Preoperative albumin			17.568	< 0.001^*
≥30 g/L	88.6	72.2			1
< 30 g/L	55.6	26.7			5.62 (2.24-14.12)	< 0.001^*
Tumor location			1.974	0.160
Others	80.6	61.5			1
Thoracic cavity	68.5	50.4			1.76 (0.78-3.94)	0.170
Pathological type			0.028	0.866
Others	59.3	59.3			1
CD	77.9	51.6			0.92 (0.34-2.47)	0.868
Skin lesions type			0.166	0.684
Others	74.3	51.3			1
Erythema multiforme-like	74.8	52.2			1.50 (0.68-3.32)	0.318
PDAI			0.267	0.875
Moderate (< 15 scores)	63.6	53.0			1
Significant (15-45 scores)	69.2	60.6			0.95 (0.38-2.43)	0.922
Extensive (>45 scores)	70.8	49.2			0.68 (0.22-2.05)	0.490
Serological biomarkers
DSG1			1.747	0.186
DSG1 (-)	77.3	57.5			1
DSG1 (+)	68.4	33.2			1.82 (0.73-4.53)	0.199
DSG3			2.744	0.254
DSG3 (-)	78.8	47.4			1
DSG3 (+)	75.0	37.5			1.73 (0.62-4.83)	0.297
BP180 (+)^b					0.59 (0.16-2.15)	0.423
Antibodies of myasthenia gravis			3.710	0.054
Antibodies of myasthenia gravis (-)	71.6	55.7			1
Antibodies of myasthenia gravis (+)	45.7	45.7			3.04 (0.92-10.06)	0.069^*
Clinical complications of PNP
Dyspnea			2.816	0.093
Without	79.5	67			1
With	71.1	46.2			0.75 (0.34-1.66)	0.481
BO			9.537	0.002^*
Without	82.5	72.8			1
With	64.3	33.4			2.97 (1.31-6.75)	0.009^*
Myasthenia gravis^b					2.49 (0.93-6.69)	0.070^*
Preoperative bacterial pulmonary infection			3.171	0.074	2.62 (1.42-9.23)	0.007^*
Without	80.3	68.8
With	75.0	25.0
Preoperative fungal infection^b					2.05 (0.61-6.90)	0.244
Treatment of PNP
Corticosteroids^b					0.79 (0.18-3.41)	0.753
Immunosuppressive agents^b					2.78 (0.82-9.41)	0.100
Gammaglobulin			0.735	0.391
Without	78.7	56.4			1
With	63.2	46.3			1.41 (0.64-3.10)	0.399
Perioperative data
Onset-to-surgical excision time/month^a					0.99 (0.95-1.04)	0.668
Surgical time/h^a					1.16 (1.00-1.33)	0.048^*
Intraoperative bleeding volume/mL^a					0.96 (0.66-1.38)	0.943
Laboratory findings at ICU admission^a
WBC/(×10⁹/L)^a					1.05 (0.94-1.18)	0.407
PaCO₂/mmHg^a					1.01 (0.97-1.05)	0.620
OI/mmHg^a					0.99 (0.98-1.00)	0.012^*
Albumin /(g/L)^a					0.88 (0.80-0.97)	0.010^*
Hgb /(g/L)^a					0.97 (0.95-1.00)	0.035^*
Worst score in ICU
APACHE Ⅱ^a					1.25 (1.10-1.42)	0.001^*
SOFA^a					2.14 (1.20-3.82)	0.010^*
Postoperative infection
PCT			3.903	0.048
Normal PCT	80.6	60.4			1
High PCT	57.2	37.5			2.41 (0.97-5.98)	0.059^*
Fungal infection			14.085	< 0.001^*
Without	81.0	67.1			1
With	53.3	16.0			6.03 (2.56-14.2)	< 0.001^*