表 2.

阿替利珠单抗PK组患者在第1周期获得的血浆PK参数(n=20)

Summary statistics for serum atezolizumab PK parameters in cycle 1 in PK cohort (n=20)

Items	Cmax/(mg/L)	Cmin/(mg/L)	AUC0-21/[d·(mg/L)]	AUC0-∞a/[d·(mg/L)]	CLb/(mL/d)
AUC0-21, area under the serum concentration-time curve from Day 1 to 21; AUC0-∞, area under the serum concentration-time curve from Day 1 to infinity; Cmax, maximum serum concentration; Cmin, minimum serum concentration; CL, clearance; CV, coefficient of variation; GM, geometric mean; PK, pharmacokinetics; SD, standard deviation. a, patients with AUC extrapolation (last PK sample to infinity in cycle 1) >30% were excluded from summary statistics; b, total clearance of drug was calculated by dose/AUC0-∞.
n	20	20	20	13	13
Mean (CV)	542 (22.3%)	102 (26.0%)	4 510 (16.6%)	5 710 (19.6%)	219 (21.2%)
SD	121	26.5	749	1 120	46.4
Minimum	377	56.1	2 970	3 780	165
Median	520	105	4 530	5 970	201
Maximum	887	143	6 100	7 280	317
GM (CV)	530 (20.9%)	98.7 (28.7%)	4 450 (17.2%)	5 600 (20.7%)	214 (20.7%)