表 1.

HBeAg阳性和阴性患者的临床特征

Clinical characteristics of HBeAg-positive and HBeAg-negative patients

Items	HBeAg positive(n=502)	HBeAg negative(n=258)	P value
a, quantitative variables that do not follow a normal distribution are expressed as M (P25, P75), and comparisons between groups are conducted using the Mann-Whitney U test; b, quantitative variables that complied with normality are expressed as mean ± standard deviation, and t-test is used in assessing the differences; c, variables are expressed as number (%), and comparisons are performed by Chi-square test. HBeAg, hepatitis B e antigen; HBV DNA, hepatitis B virus deoxyribonucleic acid; HBsAg, hepatitis B surface antigen; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphates; GGT, gamma glutamyl transferase; ALB, albumin; PA, prealbumin; PT, prothrombin time; PLT, platelet.
Age/yearsa	25 (11, 33)	39 (30, 46)	< 0.001
Gender，n(%)
Male,	307 (61.2)	149 (57.8)
Female	195 (38.8)	109 (42.2)	0.364
Serum indicators of virological
HBV DNA/(lg IU/mL)a	7.95 (7.16, 8.34)	3.50 (2.57, 4.68)	< 0.001
HBsAg/(lg IU/mL)a	4.26 (3.79, 4.68)	3.32 (2.76, 3.68)	< 0.001
Serum biochemical indicators
ALT/(U/L)a	72 (37, 170)	27 (17, 52)	< 0.001
AST/(U/L)a	53 (31, 105)	26 (20, 41)	< 0.001
ALP/(U/L)a	100 (73, 228)	77 (63, 98)	< 0.001
GGT/(U/L)a	20 (14, 38)	20 (14, 29)	0.121
Serum indicators of liver function
ALB/(g/L)a	41 (38, 43)	42 (40, 44)	< 0.001
PA/(mg/L)b	166±50	197±52	< 0.001
PT/sa	11 (11, 12)	11 (11, 12)	0.025
PLT/(×109/L)a	210 (177, 254)	186 (154, 224)	< 0.001
Histological assessment
Inflammation Grade, n (%)c
G0-G1	228 (45.4)	182 (70.5)
G2-G4	274 (54.6)	76 (29.5)	< 0.001
Fibrosis stage, n (%)c
S0-1	260 (51.8)	107 (41.5)
S2-4	242 (48.2)	151 (58.5)	0.007