表 3.

根据中国《慢性乙型肝炎防治指南(2019年版)》修改后的慢性乙型肝炎病毒感染自然病程各期特征

Characteristics of modified natural history of chronic hepatitis B virus infection in Guidelines for the Prevention and Treatment of Chronic Hepatitis B (version 2019)

Clinical characteristics/immune status	Immune tolerant phase	Immune clearance phase		Immune control phase	Reactivation phase
a, HBeAg positive chronic infection; b, HBeAg negative chronic infection; c, severer liver injury. +, positive; -, negative. HBeAg, hepatitis B e antigen; ALT, alanine aminotransferase; HBV DNA, hepatitis B virus deoxyribonucleic acid.
Modified corresponding staging	HBeAg positive chronic HBV carrier status a	HBeAg positivechronic hepatitis	HBeAg negativechronic hepatitis	Inactive HBsAg carrier status b	HBeAg negative or positive chronic hepatitisc
HBeAg	+	+	-	-	+/-
ALT	Normal	Intermittently or persistently elevated	Intermittently or persistently elevated	Normal	Intermittently or persistently elevated
Histological assessment	None/minimal inflammation and fibrosis	Moderate to severe inflammationc/fibrosis or cirrhosis	Moderate to severe inflammation/fibrosis or cirrhosisc	None/minimal inflammation and fibrosis	Moderate to severe inflammation/fibrosis or cirrhosisc
HBV DNA	High	Moderate to high	Low	Low or undetectable	Elevated