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. 2022 Sep 12;41(42):4696–4708. doi: 10.1038/s41388-022-02455-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Phenotypic representation of (A) activation-associated CD3⁺CD25⁺ T cells, cytotoxic (B) CD8⁺ and (C) CD4⁺ cells, and central memory (D) CD45RO⁺CD62L⁺ T cells, and (E) CD45RO⁺CCR7⁺ T cells of NT-T, TCR-T, and dTCR-T cells from 12 days of the bulk cell culture (three healthy donors). F, G Pie chart showing the proportion of T-cell subsets, including central memory (CM; CD45RO⁺CD62L⁺/CCR7⁺), naive (CD45RO^-CD62L⁺/CCR7⁺), effector memory (EM; CD45RO⁺CD62L^-/CCR7^-), and highly differentiated effector memory (EMRA; CD45RO^-CD62L^-/CCR7^-) cells from panels D and E. The data are presented as mean ± sd (n = 3). Statistical comparisons between dTCR-T and TCR-T groups were determined by two-tailed unpaired t tests. *P < 0.05; **P < 0.01; ***P < 0.001.