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. 2022 Sep 12;41(42):4709–4723. doi: 10.1038/s41388-022-02460-1

Fig. 7. ISCA2 is decreased in ccRCC and low ISCA2 is associated with poor patient prognosis.

Fig. 7

A Immunohistochemistry showing representative expression of ISCA2 in normal kidney (top) and in ccRCC (bottom). B Quantitation of ISCA2 H-Score in paired uninvolved and ccRCC cores from 19 patients. ****p < 0.0001 determined via Mann Whitney test. C, D Kaplan–Meier curves showing associations of (C) ISCA2 protein, or (D) ISCA2 transcript levels above (high) or below (low) the median with overall survival using a tumor microarray (TMA; 94 cases) or data from TCGA-KIRC (522 cases) respectively.