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. 2022 Oct 11;29(10):1000–1010. doi: 10.1038/s41594-022-00840-5

Fig. 5. CKM–Mediator enables gene induction via recruitment of the Mediator complex.

Fig. 5

a, A genomic snapshot of two CKM–Mediator-dependent genes, showing CDK8 and T7-MED14 ChIP–seq and cnRNA-seq in WT (+) and CKM–MED KO (-) ESCs (top) and following RA induction (bottom). b, Heatmaps showing CDK8 and T7-MED14 ChIP–seq signal at promoters (TSS±2.5 kb) of CKM–MED-dependent genes in ESCs and following RA induction (n = 631). T7-MED14 signals are shown for WT and CKM–Mediator KO RA-induced cells. Genes are sorted by decreasing T7-MED14 signal in RA-treated cells. Metaplots showing read density are shown on the top of each heatmap.