Table 2.

Roles and regulatory mechanisms of lncRNA HOXA-AS3 in human diseases and pathophysiological processes

Disease type	Role	Cell lines	Functions	Related mechanisms	Refs
Liver cancer	Tumor promoter	Hep3B, SNU-387, Li-7, SMMC-7721, HepG2, Huh7, and HCC-LM3	Cell proliferation, apoptosis, migration, and invasion	miR-29c, BMP1, miR-455-5p, and PD-L1	[23–25]
Glioma	Tumor promoter	LN229, U251, SNB19, U87, U138, and H4	Cell proliferation, apoptosis, and migration	miR-455-5p, and USP3	[25, 27]
Lung cancer	Tumor promoter	A549, PC-9, NCI-H358, and NCI-H1299	Cell proliferation, migration, invasion, cisplatin resistance	HOXA3, NF110, and HOXA6	[28–30]
Oral cancer	Tumor promoter	TSCCA, CAL-27, SCC-9, and Tca8113	Cell proliferation	miR-218-5p	[31]
Colorectal cancer	Tumor promoter	SW480, SW620, HCT116, COLO205, and LOVO	Cell proliferation, and apoptosis	miR-4319, SPNS2, and AKT	[32]
Gastric cancer	Tumor promoter	MGC-803, AGS, MKN45, SGC7901, and HGC-27	Cell proliferation, migration, and invasion	miR-29a-3p, and LTβR	[33]
Pancreatic cancer	Tumor promoter	Panc-1, Aspc-1, sw1990, and Bxpc-3	Cell proliferation	miR-29c, and CDK6	[34]
Atherosclerosis	–	HUVECs	Endothelium inflammation, cell proliferation, and apoptosis	NF-κB, miR-455-5p, p27, and Kip1	[34, 37]
Pulmonary arterial hypertension	–	HPASMCs	Cell proliferation, apoptosis, migration, and invasion	miR-675-3p, and PDE5A	[38]
MSCs lineage determination	–	MSCs	Osteogenic differentiation	EZH2, and RUNX2	[39]