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. 2022 Oct 14;12:17235. doi: 10.1038/s41598-022-22097-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representation showing the experimental protocols used in the study (n = 8). A: vehicle treated sham controls. B: GA treated sham controls. C: unprotected ischemia–reperfusion control (Ctr). D: protection with 2 or 4 weeks GA in the drinking water, E: IV infused GA, F: GA infused with the perfusion buffer 5 min before reperfusoin and continued for 10 min after the start of reperfusion. GA Gum Arabic, IV intravenous injection.