Table 4.
Comparison of baseline data by normal or elevated ONSD/ED.
| Demographics | Normal ONSD/ED 43 patients |
Elevated ONSD/ED 11 patients |
p-value |
|---|---|---|---|
| Age, mean (CI) | 63 (59 to 67) | 66 (62 to 71) | 0.12 |
| Male, % | 81% | 73% | 0.67 |
| Comorbidities | |||
| Cardiovascular disease, % | 18% | 18% | 1.0 |
| Asthma/COPD, % | 14% | 0 | 0.33 |
| Diabetes, % | 23% | 36% | 0.45 |
| Obesity, % | 37% | 27% | 0.73 |
| Hypertension, % | 35% | 55% | 0.31 |
| Treatments | |||
| Vasopressors at time of ONSD/ED measurement, % | 67% | 81% | 0.47 |
| Inotropes at time of ONSD/ED measurement, % | 9% | 18% | 0.59 |
| Ventilator mode at time of ONSD/ED measurement, pressure support, % | 44.2% | 54.5% | 0.74 |
| Ventilator mode at time of ONSD/ED measurement, pressure control, % | 55.8% | 45.5% | 0.74 |
| PEEP at time of ONSD/ED measurement, mean (CI) | 11.2 (10.2 to 12.2) | 11.5 (10.2 to 12.7) | 0.73 |
| Pressure support/pressure control at time of ONSD/ED measurement, mean (CI) | 14.0 (12.7 to 15.4) | 12.9 (10.0 t0 15.8) | 0.45 |
| Peak airway pressure at time of ONSD/ED measurement, mean (CI) | 25.2 (23.7 to 26.8) | 24.4 (20.9 to 27.8) | 0.62 |
| Accumulated time of prone positioning at time of ONSD/ED measurement, mean (CI) | 38.2 (27.8 to 48.4) | 37.1 (12.1 to 62.1) | 0.93 |
| Other baseline data | |||
| PFI (ratio of pO2 in kPa to FiO2) at time of ONSD/ED measurement, mean (CI) | 19 (17 to 21) | 18 (14 to 22) | 0.32 |
| pCO2 (kPa) at time of ONSD/ED measurement, mean (CI) | 6.7 (6.2 to 7.2) | 6.0 (5.1 to 6.9) | 0.08 |
| Acute Kidney Injury (AKI) at time of ONSD/ED measurement, % | 19% | 18% | 1.0 |
| ICU day of ONSD/ED measurement, median (interquartile range) | 6 (3 to 13) | 8 (5 to 15) | 0.74 |
CI confidence interval, n numbers, COPD chronic obstructive pulmonary disease, ONSD/ED optic nerve sheath diameter divided by eyeball diameter, PFI ratio of partial pressure of oxygen (kPa) in arterial blood divided by fraction of inspired oxygen, pCO2 partial pressure of carbon dioxide (kPa) in arterial blood, AKI acute kidney injury, ICU intensive care unit.