Table 3.
Univariable and multivariable Cox proportional hazard analyses between preoperative characteristics and early recurrence.
| Variables | Univariable | Multivariable with LNOR | Multivariable with LNAND | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | HR | 95% CI | p-value | |
| Age | 0.989 | 0.963–1.016 | 0.417 | – | – | – | – | – | – |
| Male sex | 1.180 | 0.688–2.025 | 0.547 | – | – | – | – | – | – |
| BMI (kg/m2) | 0.953 | 0.864–1.051 | 0.338 | – | – | – | – | – | – |
| Preoperative CA19-9 (× 100 U/mL) | 1.008 | 1.002–1.015 | 0.012 | 1.009 | 1.002–1.016 | 0.010 | 1.011 | 1.004–1.017 | 0.003 |
| Tumor size | 0.996 | 0.981–1.011 | 0.563 | – | – | – | – | – | – |
| Head location | 1.523 | 0.891–2.604 | 0.124 | – | – | – | – | – | – |
| Positive uptake of tumor on FDG-PET scan | 1.385 | 0.543 – 3.529 | 0.495 | ||||||
| NCCN resectability | 0.020 | < 0.001 | 0.023 | ||||||
| Resectable | 1 | Reference | 1 | Reference | 1 | Reference | |||
| Borderline resectable | 1.748 | 0.817–3.737 | 0.150 | 1.551 | 0.705–3.413 | 0.275 | 1.382 | 0.732–2.612 | 0.319 |
| Locally advanced (unresectable) | 2.797 | 1.249–6.262 | 0.012 | 2.445 | 1.073–5.571 | 0.033 | 2.649 | 1.275–5.507 | 0.009 |
| LNOR | 2.382 | 1.278–4.442 | 0.006 | 2.027 | 1.057–3.885 | 0.033 | – | – | – |
| LNAND | 2.494 | 1.287–4.835 | 0.007 | – | – | – | 2.086 | 1.054–4.125 | 0.035 |
HR, hazard ratio; CI, confidence interval; BMI, body mass index; CA19-9, carbohydrate antigen 19–9; FDG-PET, 18F-fluoro-2-deoxyglucose-positron emission tomography; LNOR, regional LN metastasis on preoperative CT or FDG-PET scans; LNAND, regional LN metastasis on preoperative CT and FDG-PET scans; NCCN, National Comprehensive Cancer Network.
Significant values are in [bold].