Table 2.
KIR gene frequencies among patients with lung cancer and healthy controls.
| KIR genes | Healthy controls | Lung cancer | Comparisons | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Lung cancer | NSCLC | SCLC | Lung cancer versus HC | NSCLC versus HC | SCLC versus HC | |||||
| n = 448 | n = 232 | n = 179 | n = 53 | p value | OR (95% CI) | p value | OR (95% CI) | p value | OR (95% CI) | |
| %F (N + /n) | %F (N + /n) | %F (N + /n) | %F (N + /n) | |||||||
| Group-A haplotype-associated KIR genes | ||||||||||
| 2DL1 | 98.0 (439/448) | 97.4 (226/232) | 97.2 (174/179) | 98.1 (52/53) | ||||||
| 2DL3 | 88.2 (395/448) | 85.3 (198/232) | 84.4 (151/179) | 88.6 (47/53) | ||||||
| 3DL1 | 92.6 (415/448) | 95.3 (221/232) | 96.6 (173/179) | 92.4 (49/53) | ||||||
| 2DS4 | 92.9 (416/448) | 94.8 (220/232) | 95.5 (171/179) | 92.4 (49/53) | ||||||
| 2DS4fl | 12.9 (31/242) | 10.4 (18/174) | 10.2 (14/137) | 10.8 (4/37) | ||||||
| 2DS4del | 73.5 (178/242) | 70.6 (123/174) | 70.8 (97/137) | 70.3 (26/37) | ||||||
| 2DS4fl,del | 13.6 (33/242) | 19.0 (33/174) | 19.0 (26/137) | 18.9 (7/37) | ||||||
| Group-B haplotype-associated KIR genes | ||||||||||
| 2DL2 | 55.4 (248/448) | 67.2 (156/232) | 65.9 (118/179) | 71.6 (38/53) | 0.003 | 1.63 (1.17–2.26) | 0.016 | 1.56 (1.087–2.24) | 0.027 | 2.04 (1.09–3.82) |
| 2DL5 | 66.1 (296/448) | 63.8 (148/232) | 64.2 (115/179) | 62.2 (33/53) | ||||||
| 3DS1 | 47.3 (212/448) | 37.5 (87/232) | 36.8 (66/179) | 39.6 (21/53) | 0.015 | 0.67 (0.48–0.92) | 0.02 | 0.65 (0.43–0.93) | ||
| 2DS1 | 50.2 (225/448) | 41.4 (96/232) | 41.3 (74/179) | 41.5 (22/53) | 0.029 | 0.69 (0.5–0.95) | ||||
| 2DS2 | 54.5 (244/448) | 62.9 (146/232) | 62.0 (111/179) | 66.0 (35/53) | 0.041 | 1.42 (1.02–1.96) | ||||
| 2DS3 | 41.5 (186/448) | 40.1 (93/232) | 39.6 (71/179) | 41.5 (22/53) | ||||||
| 2DS5 | 39.5 (177/448) | 32.8 (76/232) | 32.9 (59/179) | 32.0 (17/53) | ||||||
| Framework genes/pseudogenes | ||||||||||
| 2DL4 | 100 (448) | 100 (232) | 100 (179) | 100 (53) | ||||||
| 3DL2 | 100 (448) | 100 (232) | 100 (179) | 100 (53) | ||||||
| 3DL3 | 100 (448) | 100 (232) | 100 (179) | 100 (53) | ||||||
| 2DP1 | 97.8 (438) | 96.1 (223) | 94.9 (170) | 100 (53) | ||||||
| 3DP1 | 100 (448) | 100 (232) | 100 (179) | 100 (53) | ||||||
N+ number of individuals positive for the gene, n number of individuals tested for the gene, HC healthy control, OR odds ratio, CI confidence interval. p < 0.05: statistically significant; based on two-tailed Fisher’s exact test.