Table 4.
KIR genotype frequencies among patients with lung cancer and healthy controls.
| KIR | Healthy controls | Lung cancer | Comparisons | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Lung cancer | NSCLC | SCLC | Lung cancer versus HC | NSCLC versus HC | SCLC versus HC | |||||
| n = 448 | n = 232 | n = 179 | n = 53 | p value | OR (95% CI) | p value | OR (95% CI) | p value | OR (95% CI) | |
| %F (N+) | %F (N+) | %F (N+) | %F (N+) | |||||||
| KIR genotypes | ||||||||||
| AA | 25.7 (115) | 19.4 (45) | 19.5 (35) | 16.9 (9) | ||||||
| Bx | 74.3 (333) | 80.6 (187) | 80.4 (144) | 83.1 (44) | ||||||
| CxT4 | 22.7 (102) | 17.6 (41) | 18.4 (33) | 15.0 (8) | ||||||
| C4Tx | 23.4 (105) | 28.4 (66) | 29.6 (53) | 24.5 (13) | ||||||
| C4T4 | 12.7 (57) | 9.5 (22) | 8.37 (15) | 13.2 (7) | ||||||
| CxTx | 15.4 (69) | 25.0 (58) | 24.0 (43) | 30.2 (16) | 0.0035 | 1.83 (1.23–2.71) | 0.015 | 1.74 (1.13–2.66) | 0.011 | 2.37 (1.25–4.5) |
| C4 Linkage groups | 36.2 (162) | 37.9 (88) | 37.9 (68) | 37.7 (20) | ||||||
| T4 Linkage groups | 35.4 (159) | 27.1 (63) | 26.8 (48) | 28.3 (15) | 0.03 | 0.67 (0.47–0.97) | 0.0039 | 0.66 (0.45–0.97) | ||
N + number of individuals positive for the gene, n number of individuals tested for the gene, HC healthy control, OR odds ratio, CI confidence interval. p < 0.05: statistically significant; based on two-tailed Fisher’s exact test.