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(A) Ribbon structure of Mfn1IM dimer in the open conformation bound to GDP (PDB: 5GOM) with the GTPase domain of one protomer in goldenrod, the second GTPase domain in dark blue, helical bundle 1 (HB1) in magenta, S329 highlighted in cyan, and GDP in red. (B) Structure of Mfn1IM dimer in the closed conformation bound to transition-state mimic GDP-BeF3− in red (PDB: 5YEW).
