Table 1. Baseline Characteristics According to Prediagnosis BMI Category.
| Variable | Patients, No. (%) | P value | |||
|---|---|---|---|---|---|
| Total | Normal (<25) | Overweight (25-30) | Obese (≥30) | ||
| No. of patients | 656 | 251 (38.3) | 238 (36.3) | 167 (25.4) | NA |
| Age at initial diagnosis, y | |||||
| <45 | 135 (20.6) | 80 (31.9) | 29 (12.2) | 26 (15.6) | <.001 |
| 45-65 | 414 (63.1) | 147 (58.6) | 158 (66.4) | 109 (65.3) | |
| ≥65 | 107 (16.3) | 24 (9.6) | 51 (21.4) | 32 (19.2) | |
| Sex | |||||
| Men | 376 (57.3) | 80 (31.9) | 176 (73.9) | 120 (71.9) | <.001 |
| Women | 280 (42.7) | 171 (68.1) | 62 (26.1) | 47 (28.1) | |
| Race | |||||
| Black or Hispanic | 105 (16.0) | 34 (13.6) | 40 (16.8) | 31 (18.6) | .03 |
| Non-Hispanic White | 501 (76.4) | 188 (74.9) | 183 (76.9) | 130 (77.8) | |
| Othera | 50 (7.6) | 29 (11.6) | 15 (6.3) | 6 (3.6) | |
| Smokingb | |||||
| Ever | 256 (39.3) | 85 (34.0) | 89 (37.6) | 82 (50.0) | .004 |
| Never | 395 (60.7) | 165 (66.0) | 148 (62.4) | 82 (50.0) | |
| Diabetesc | |||||
| Yes | 92 (14.2) | 18 (7.2) | 31 (13.2) | 43 (26.1) | <.001 |
| No | 556 (85.8) | 231 (92.8) | 203 (86.8) | 122 (73.9) | |
| Stage at diagnosisd | |||||
| I | 18 (2.8) | 7 (2.8) | 8 (3.4) | 3 (1.8) | .15 |
| II | 53 (8.1) | 17 (6.8) | 17 (7.2) | 19 (11.5) | |
| III | 196 (30.1) | 86 (34.5) | 59 (25.0) | 51 (30.7) | |
| IV | 384 (59.0) | 139 (55.8) | 152 (64.4) | 93 (56.0) | |
| Total KRAS variations | 549 | 206 (37.5) | 199 (36.3) | 144 (26.2) | |
| WT | 272 (49.5) | 104 (50.5) | 93 (46.7) | 75 (52.1) | .75 |
| Canonical | 270 (49.2) | 100 (48.5) | 102 (51.3) | 68 (47.2) | |
| Noncanonical | 7 (1.3) | 2 (1.0) | 4 (2.0) | 1 (0.7) | |
| Total PIK3CA variations | 474 | 187 (39.5) | 170 (35.9) | 117 (24.7) | |
| WT | 364 (76.8) | 143 (76.5) | 124 (72.9) | 97 (82.9) | .14 |
| Mutant | 110 (23.2) | 44 (23.5) | 46 (27.1) | 20 (17.1) | |
| Tumor locatione | 622 | 237 (38.1) | 224 (36.0) | 161 (25.9) | |
| Right | 215 (34.6) | 75 (31.7) | 83 (37.1) | 57 (35.4) | .48 |
| Left | 277 (44.5) | 110 (46.4) | 91 (40.6) | 76 (47.2) | |
| Rectum | 130 (20.9) | 52 (21.9) | 50 (22.3) | 28 (17.4) | |
Abbreviations: BMI, body mass index; WT, wild-type variation.
a
Other race includes Asian or Pacific Islander, American Indian or Alaska Native, and other or not specified.
b
Results on smoking include 5 missing data, including 1 patient with normal, 1 with overweight, and 3 with obese BMI.
c
Results on diabetes include 8 missing data, including 2 patients with normal, 4 with overweight, and 2 with obese BMI.
d
Results on stage at diagnosis include 5 missing data, including 2 patients with normal, 2 with overweight, and 1 with obese BMI.
e
Data missing on 34 tumors, including for 14 patients with normal, 14 with overweight, and 6 with obese BMI.