Fig. 4. Effect of nafamostat on experimental infection of WT mice with various SARS-CoV-2 strains.
a Schematic of the experimental protocol. C57BL/6 mice were treated intranasally with nafamostat (100 µg/head) and 2 hours later, they were infected with Beta, a Gamma and an Omicron variant of SARS-CoV-2 (1 × 104 TCID50 in 25 µl) b Lung virus titres measured at 1 day post-infection (n = 6 mice per group). The detection limit was 101.5 TCID50/g of tissue. *P = 0.0195, **P = 0.0065, P = 0.2273 (Omicron) by two-tailed Mann–Whitney U test. Data are mean ± SD.