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. 2022 Oct 15;13:6105. doi: 10.1038/s41467-022-33880-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Membrane view of H₃R–PF-03654746 structure. H₃R was shown in forest green ribbons. PF-03654746 was shown in a magenta sphere. The disulfide bond was shown as orange sticks. b, c Structural comparison of H₃R (forest green) with inactive H₁R (gray, PDB ID: 3RZE) and active H₁R (pink, PDB ID: 7DFL) from extracellular view (b) and intracellular view (c). d Intracellular view showing a salt-bridge interaction (yellow dashed line) between D131^3.49 and R132^3.50. The red arrows indicated movements of TMs5/6 and ECL2 in the H₃R structure compared to the H₁R inactive structure.