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. 2022 Oct 15;13:6105. doi: 10.1038/s41467-022-33880-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Superpositions of the ligand-binding pockets of H₃R–PF-03654746 (H₃R in forest green, PF-03654746 in violet), H₁R–Doxepin (PDB ID: 3RZE, H₁R in gray, Doxepin in yellow), and H₁R–Histamine (PDB ID: 7DFL, H₁R in pink, Histamine in green) from the membrane view. Structural comparisons of the toggle switch (b), PIF motif (c), DRY motif (d), and NPxxY motif (e) with the same colors as a.