Table 1.
In vivo and in vitro anticancer activities of medicinal plants and their active constituents
| Plant’s name | Common name | Parts utilized | Tested on cancer cell lines | Animal Models | References |
|---|---|---|---|---|---|
| Allium sativum | Garlic | Leaves | WEHI 164 cells | Balb/c mice | Shirzad et al. (2011) |
| Alpinia galanga | Lengkuas, blue ginger | Rhizomes | DLA and A549 cells | Balb/c mice | Lakshmi et al. (2019) |
| Alstonia scholaris | Blackboard | Stem bark | HeLa cells | Mice | Mondal et al. (2012) |
| Andrographis paniculata | Green chiretta | Aerial parts | SW620 and A-498 cells | Swiss Albino mice | Khan et al. (2020) |
| Angelica archangelica | Wild celery | Root and rhizome | MCF-7 and 4T1 cells |
Balb/c Mice Female |
Oliveira et al. (2019) |
| Aralia elata | Japanese angelica tree | Leaves | MCF-7 cells |
Tumor Bearing-nude Mice |
Li et al. (2019) |
| Asclepias curassavica | Tropical milkweed | Shade dried leaves | COLO320 DM cells | Wistar male rats | Baskar et al. (2010) |
| Brassica napus | Mustard | Roots and leaves | Renal, prostate, oral, colorectal lung, and breast cancer | – | Thomson et al. (2010) |
| Copaifera multijuga | Hayne oil | Tree trunk | B16-F10 cells | MaleC57/black Mice | Carneiro et al. (2020) |
| Coptidis rhizoma | Huanglian, Copaiba | Root | HepG2 and MHC97-l cells | – | Wang et al. (2010) |
| Curcuma longa | Turmeric | Rhizome | Ht-29 cells | – | Khan et al. (2020) |
| Elephantopus scaber | Elephants Foot | Whole plant | EAC cells | Swiss male albino mice | Kabeer et al. (2019) |
| Garcinia indica | Kokum | Fruits | HCT-116 andHT -29 cells | – | Khan et al. (2020) |
| Garcinia oblongifolia | Lingnan garcinia | Branch | MCF -7 cells | – | Li et al. (2016) |
| Hedyotis diffusa | White flower Snake-tongue grass | HeLa cells | Nude xenograft mice | Li et al. (2012) | |
| Kaempferia parviflora | Black ginger | Rhizomes | SKOV3 cells | – | Paramee et al. (2018) |
| Loranthus parasiticus | Mulberry Mistletoe | Leaves | SKOV-3, CAOV-3, OVCAR-3 cells | Rat | Moghadamtousi et al. (2014) |
| Menyanthes trifoliata | Bogbean, Buckbean | Aerial part and root | Grade IV glioma cells | – | Kowalczyk et al. (2019) |
| Morus alba | white mulberry | Root | HL-60 and CRL-1579 cells | – | Kikuchi et al. (2010) |
| Morus nigra | Blackberry | Airy portion | PC-3 cells | – | Turan et al. (2017) |
| Nitraria retusa | Salt tree | Leaves | B16-F10 cells | Balb/c mice | Boubaker et al. (2018) |
| Paris polyphylla | Herb Paris | Rhizomes | A549 cells | c57bl/6mice | Li et al. (2013) |
| Perilla frutescens | Beefsteak plant | Leaves | Huh-7 cells | Tumor nude xenograft mice | Wang et al. (2013 |
| Prunus armeniaca | Apricot | Fruit, seeds | HCT116, MCF-7 andHep G2 cells | Rat | Gomaa (2013) |
| Platycodon grandiflorus | Balloon flower | Root | MCF-7 cells | – | Yu et al. (2010) |
| Rabdosia rubescens | Bing Ling | Whole plant | SGC-996 andNOZ cells |
Nude athymic Mice |
Bao et al. (2014) |
| Rhizoma curcumae | Turmeric | Rhizome | JF- 305 andMCF-7cells | Tropical fish | Zhu et al. (2019) |
| Scutellaria barbata | Barbed Skullcap | Whole plant | 95-D cells | Xenograft | Yang et al. (2014) |
| Scutellaria baicalensis | Baikal skullcap | Root | OSCC cells | – | Sato et al. (2013) |
| Tussilago farfara | Coltsfoot | Flower buds | HT-29 cells | – | Lee et al. (2014) |
| Withania somnifera | Ashwagandha | Leaves, roots, stem and flower | MCF-7 (breast), WRL-68 (liver), PC-3 (prostate) and CACO-2 | – | Siddique et al. (2014) Srivastava and Sangwan (2020) |
| Wedelia chinensis |
Chinese Wedelia |
Leaves | B16-F10 cells | C57bl/6 mice | Manjamalai and Grace (2012) |