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. 2022 Sep 29;23(19):11519. doi: 10.3390/ijms231911519

Figure 5.

Figure 5

D127N KI mouse platelets have a significantly inhibited response to ADP. (A) Representative tracings showing aggregation in response to either 5 or 10 μM ADP of platelets isolated from WT, Het, or KI mice. (B,C) Quantitiation of platelet aggregation in response to 5 or 10 μM ADP. (D) Representative aggregation and secretion tracings of platelets isolated from WT, Het, and KI mice stimulated with 200 or 500 μM AYPGKF. (E,F) Quantitation of aggregation (E) and secretion (F) from WT, Het, and KI platelets stimulated with 200 μM AYPGKF. (G,H) Quantitation of aggregation (G) and secretion (H) from WT, Het, and KI platelets stimulated with 500 μM AYPGKF.