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. 2022 Sep 24;23(19):11249. doi: 10.3390/ijms231911249

Table 2.

Pharmacokinetic parameters for oxytocin (OXT) [2] and ASK2131 following subcutaneous (sc) administration to rats and mice.

Compound Route CLplasma, mL/min/kg Vd, L/kg Cmax/Free Cmax, nM Tmax, Hour T1/2, Hour
OXT, sc (rat) [18] 17.1 0.085 0.12
OXT, sc (mouse) [18] 216/191 0.25 0.5
ASK2131, sc (rat) 1.20 0.80 276/0.5 4.00 2.30