Table 3.
Pre- and post-treatment body measures, and post treatment serum levels.
| Vehicle | Oxytocin | ASK2131 | ASK2131 Pair | |
|---|---|---|---|---|
| n= | 6 | 6 | 6 | 6 |
| Pretreatment body weight (g) | 762 ± 64 | 719 ± 18 | 723 ± 38 | 724 ± 43 |
| Posttreatment body weight (g) | 799 ± 69 | 719 ± 20 | 676 ± 42 | 691 ± 41 |
| % change in body weight | 4.9 ± 1.1 | 0.1 ± 1 b | −6.6 ± 1.3 c,d | −4.6 ± 0.6 |
| Glucose (mg/dL) | 232 ± 8 | 203 ± 13 | 237 ± 12 | 256.± 13 |
| Triglycerides (mg/dL) | 190 ± 10 | 145 ± 7 | 182 ± 30 | 128 ± 7 |
| Cholesterol (mg/dL) | 102 ± 8 | 76 ± 3 | 67 ± 6 b | 73 ± 6 a |
| HDL (mg/dL) | 28 ± 3 | 25 ± 2 | 21 ± 2 | 23 ± 2 |
| Calculated LDL (mg/dL) * | 31 ± 5 | 22 ± 2 | 15 ± 5 | 24 ± 5 |
| ALT (U/L) | 44 ± 13 | 40 ± 5 | 26 ± 2 | 28 ± 3 |
| AST (U/L) | 117 ± 30 | 128 ± 22 | 73 ± 8 | 100 ± 8 |
| Leptin (mg/dL) | 55.5 ± 11.1 | 54.9 ± 7.9 | 39.0 ± 9.1 | 37.8 ± 8.0 |
| Insulin (ng/mL) | 5.6 ± 1.5 | 7.2 ± 2.1 | 6.7 ± 1.0 | 10.2 ± 2.6 |
| Adiponectin (ng/mL) | 76.2 ± 2.7 | 60.8 ± 3.9 | 62.4 ± 7.3 | 48.2 ± 6.4 |
a: p < 0.05 vs. vehicle b: p < 0.01 vs. vehicle c: p < 0.001 vs. vehicle d: p < 0.001 vs. OXT. Data expressed as mean ± SEM. Primary Analysis for normal distribution: One-Way ANOVA test assuming equal variances or Welch’s ANOVA for unequal variances; Šídák’s multiple comparisons test was used for post hoc analyses in both instances. For non-normally distributed data: Kruskal–Wallis test with Dunn’s multiple comparison test assuming equal variances or Brown-Forsythe ANOVA test with Dunnett’s T3 multiple comparison test for unequal variances. Serum measures were only available for n = 4 of the Oxytocin treated animals. * Calculated LDL = Cholesterol − (HDL + Triglycerides/5).