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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
MAPK pathway (left) and immunosuppressive role of KRAS (right) mediated by upregulation of PDL-1, increased Tregs and MDSCs in TME, and downregulation of MHC-I.