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. 2022 Oct 6;23(19):11850. doi: 10.3390/ijms231911850

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Modeling steatosis development. (A) (Top) Tissue features observed in liver biopsies from patients with steatosis. (Bottom) The major molecular and cellular changes during steatosis development in the liver. (B) (Top) Steatosis phenotypes observed in the hepatocytes are well recapitulated using various culture systems discussed. (Bottom) Legend for diagrams in Figure 2, Figure 3 and Figure 4.