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. 2022 Oct 6;23(19):11850. doi: 10.3390/ijms231911850

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Modeling NASH development. (A) (Top) Tissue features observed in liver biopsies from patients with NASH. (Bottom) The major molecular and cellular changes during NASH development in the liver. This includes hepatocyte injury and cell death, immune cell infiltration and inflammation, fibrogenesis, LSEC capillarization, and ductular reaction. (B) (Left) NASH-associated cellular changes captured using monolayer cultures of hepatocytes and HSC. (Right) NASH-associated cellular and structural changes observed in the hepatocytes recapitulated using various 3D culture systems described.