Table 2.

Claudin expression in the OSCC and clinicopathological features.

Clinicopathological Features	Number	Claudin-1	Claudin-2	Claudin-4	Claudin-5	Claudin-7
Age at diagnosis	60	r = −0.092 p = 0.484	r = 0.072 p = 0.583	r = 0.159 p = 0.225	r = −0.0612 p = 0.641	r = −0.028 p = 0.831
Sex: Male   Female	38 22	R = 33.08 R = 26.05 p = 0.133	R = 29.12 R = 32.86 p = 0.425	R = 28.61 R = 33.77 p = 0.269	R = 31.45 R = 28.86 p = 0.581	R = 28.63 R = 33.73 p = 0.276
Nicotine: yes     no Not specified	34 7 19	R = 22.15 R = 15.43 p = 0.177	R = 21.56 R = 18.29 p = 0.510	R = 21.15 R = 20.29 p = 0.862	R = 20.74 R = 22.29 p = 0.755	R = 21.38 R = 19.14 p = 0.652
Alcohol: yes     no Not specified	26 2 32	R = 14.85 R = 10 p = 0.422	R = 14.15 R = 19 p = 0.422	R = 13.88 R = 22.50 p = 0.153	R = 14.31 R = 17 p = 0.656	R = 14.04 R = 20.50 p = 0.284
UICC stage  (0–IVa,b,c) Not specified	52 8	r = 0.160 p = 0428	r = 0.090 p = 0.965	r = 0.005 p = 0.560	r = 0.085 p = 0.208	r = −0.367 p = 0.008 **
T stage  (Tis–T4) Not specified	59 1	r = −0.089 p = 0.503	r = 0.042 p = 0.752	r = −0.227 p = 0.083	r = −0.209 p = 0.112	r = −0.213 p = 0.106
Lymph node status  (N0–N2a,b,c) Not specified	54 6	r = 0.150 p = 0.279	r = −0.018 p = 0.898	r = −0.014 p = 0.920	r = 0.010 p = 0.940	r = −0.387 p = 0.004 **
Histological differ entiation (G1–G3) Not specified	52 8	r = 0.040 p = 0.780	r = −0.073 p = 0.609	r = 0.006 p = 0.965	r = 0.047 p = 0.740	r = −0.046 p = 0.747
Lymphovascular invasion:     yes     no Not specified	6 41 13	R = 34.17 R = 22.51 p = 0.052	R = 21.50 R = 24.37 p = 0.633	R = 29.17 R = 23.24 p = 0.323	R = 30.67 R = 23.02 p = 0.202	R = 25 R = 23.85 p = 0.848

Calculation with the Spearman-Rho or Mann-Whitney-U test with a significant result at ** p <0.01. (r = rank correlation coefficient; R = middle rank).