Table 2.
Multivariate Cox regression analyses on the impact of the genotype of HSD17B13 rs72613567 on liver transplantation, mortality, and hepatic decompensation.
| Liver Transplantation | Mortality | Liver-Related Death | Any (Further) Decompensation |
|||||
|---|---|---|---|---|---|---|---|---|
| aHR (95% CI) |
p-Value | aHR (95% CI) |
p-Value | aHR (95% CI) |
p-Value | aHR (95% CI) |
p-Value | |
| Sex | 1.96 (0.87–4.32) |
0.097 | 1.17 (0.71–1.93) |
0.531 | 1.27 (0.72–2.21) |
0.404 | 1.04 (0.64–1.70) |
0.880 |
| Age | 0.98 (0.95–1.00) |
0.089 | 1.05 (1.03–1.07) |
0.001 | 1.05 (1.03–1.08) |
0.001 | 1.04 (1.02–1.06) |
0.001 |
| MELD | 1.09 (1.04–1.15) |
0.001 | 1.09 (1.05–1.14) |
0.001 | 1.11 (1.07–1.16) |
0.001 | 1.29 (1.21–1.38) |
0.001 |
| Etiological factors | 1.52 (0.81–2.84) |
0.197 | 1.52 (0.97–2.39) |
0.069 | 1.39 (0.84–2.30) |
0.204 | 1.99 (1.29–3.07) |
0.002 |
| rs72613567 TA/TA genotype | 1.21 (0.49–2.93) |
0.673 | 1.67 (0.91–3.18) |
0.089 | 2.32 (1.20–4.46) |
0.012 | 2.37 (1.09–5.06) |
0.029 |
MELD: Model for End-Stage Liver Disease; etiological factors: relapse in alcohol intake or active viral infection.