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. 2022 Oct 1;23(19):11636. doi: 10.3390/ijms231911636

Figure 1.

Figure 1

The inhibitory effect of evogliptin on lipopolysaccharide (LPS)-induced cytokine secretion from Kupffer cells. (A) Primary Kupffer cells (KC) were pretreated with LPS for 2 h and then treated with evogliptin. After 24 h, the media was collected and measured using ELISA. The data are the mean ± SEM of three independent measurements. ** p < 0.01 relative to the control, ## p < 0.01 relative to LPS. (B) Representative real-time RT-PCR analysis of the expression levels of iNOS, IL1β, IL6, and TNFα in primary hepatocytes treated with conditioned media (CM) from LPS-treated primary KC. The data are the mean ± SEM. ** p < 0.01 relative to the control, ## p < 0.01 relative to LPS. (C) Representative real-time RT-PCR analysis of the expression levels of αSMA and collagen in primary hepatocytes treated with CM from LPS-treated primary hepatic stellate cells. Data are the mean ± SEM. ** p < 0.01 relative to the control, # p < 0.05, ## p < 0.01 relative to LPS.