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. 2022 Oct 1;23(19):11636. doi: 10.3390/ijms231911636

Figure 5.

Figure 5

Induction of autophagy is required for evogliptin to prevent inflammatory and fibrotic signaling in liver cells. (A) Real-time RT-PCR analysis of the effect of evogliptin on LPS-induced inflammatory signaling in primary hepatocytes from ATG7f/f-Cre+ mice. ** p < 0.01 relative to the control,# p < 0.05, ## p < 0.01 relative to LPS. (B) iNOS production and cytokine secretion in primary hepatocytes from ATG7f/f-Cre+ mice. ** p < 0.01 relative to the control, # p < 0.05, ## p < 0.01 relative to LPS. (C) Western blot analysis of the effect of evogliptin on TGF-β-induced CTGF expression in primary hepatocytes from ATG7f/f-Cre+ mice. Data in the bar graph are represented as the mean ± SEM. * p < 0.05 relative to the control, # p < 0.05 relative to TGF-β.