Figure 1.

(a) Transepithelial conductance, G, in HBEC epithelial monolayers expressing WT (non-CF) and F508del mutant CFTR (CF). Measurements (n = 10 for both conditions) were obtained after treatment with DMSO as vehicle. (b) Difference between transepithelial conductances measured before and after the different treatments (∆G), measured in epithelia expressing the F508del mutation. (DMSO: 0.1% DMSO (vehicle control), iva: 1 µM of ivacaftor, tez: 5 µM of tezacaftor, ele: 5 µM of elexacaftor, mix: 1 µM of ivacaftor + 5 µM of tezacaftor + 5 µM of elexacaftor). The sample size, n, was comprised between 6 ≤ n ≤ 9. Asterisks indicate that the ∆G value is significantly different from that measured in CF HBEC treated with the DMSO vehicle.