Figure 2.

Fluid reabsorption, J_W, of HBEC monolayers, cultured on Transwell permeable supports, from non-CF cells treated with 0.1% DMSO (vehicle control) and CF HBEC treated with 0.1% DMSO (vehicle control), 1 µM of ivacaftor (iva), 5 µM of tezacaftor (tez), 5 µM of elexacaftor (ele), 1 µM of ivacaftor + 5 µM of tezacaftor + 5 µM of elexacaftor (Mix) for 48 h. Fluid reabsorption of each sample was evaluated gravimetrically as described in the Section 4. The white circles represent the values of each individual measure (6 ≤ n ≤ 12). The section mark (§) indicates data that are statistically different from non-CF control cells, while asterisks (*) indicate a statistical significance versus control CF cells.