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Cell viability: (A). breast cancer cells; (B). osteosarcoma cells. Cells were incubated 72 h with 5 µM with free DOXO, free H2S-DOXO NP-H2S-DOXO 3% PVP, and HA-NP-CTAB-H2S-DOXO (containing 5 µM H2S-DOXO), then the release of LDH was measured by a chemiluminescence-based assay (n = 4). Data are means + SD. *** p < 0.001: versus ctrl; °°° p < 0.001: versus DOXO; # p < 0.05: versus H2S-DOXO.
