Figure 1.

Compounds and conditions that sustainably activate the tubuloglomerular feedback (TGF) mechanism. Compounds that decrease solute reabsorption in the proximal tubule/loop of Henle can sustainably increase macula densa (MD) delivery unless there is a compensation in the reabsorption in segments proximal to the macula densa (left). Sustained increase in macula densa delivery would lead to sustained activation of the TGF system unless there is a compensation in the TGF response (right). Sustained activation of the TGF mechanism would result in sustained alteration of single nephron hemodynamics and presumable enhancement of synchronization among nephrovascular units (NVUs) (center).