TABLE 3.
Mean ± SEM levels of cytokines and inflammatory mediators in sputum
| Cytokine or inflammatory mediator in sputum (amt) | Level of cytokine or inflammatory
mediator
|
Significancea | ||
|---|---|---|---|---|
| Clinic | Exacerbation day 0 to 1 | Exacerbation day 2 to 10+ | ||
| IL-8 (ng/liter) | 14,732 ± 1,297 | 13,617 ± 1,695 | 12,072 ± 1,968 | 0.324 |
| TNF (ng/liter) | 210 ± 28.4 | 306 ± 40.7 | 235 ± 68.7 | 0.230 |
| NE complex (μg/liter) | 105.2 ± 11.6 | 113.1 ± 11.9 | 99.4 ± 13.7 | 0.078 |
| α-1-PI (g/liter) | 0.05 ± 0.002 | 0.08 ± 0.01 | 0.10 ± 0.02 | 0.002 |
| Protein (g/liter) | 1.07 ± 0.06 | 1.29 ± 0.09 | 1.33 ± 0.12 | 0.001 |
| NE complex/g of protein | 116 ± 19.19 | 101 ± 12.7 | 80 ± 10.3 | 0.340 |
| α-1-PI/g of protein | 0.05 ± 0.005 | 0.06 ± 0.007 | 0.06 ± 0.01 | 0.039 |
a
Overall significance of differences in means across clinic and exacerbation day 0 to 1 and day 2 to 10 assessments. Paired significances were not tabulated.