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. 2022 Oct 4;23(19):11757. doi: 10.3390/ijms231911757

Figure 4.

Figure 4

Fluorescence microscopy of CD20 (red) and CD44 (green) double staining of the eyes in the PDX PCNSL vs. PDX SCNSL group. (A–C) show recordings of the choroid, (D–F) of the retina and (G–I) of the ciliary body (marked with *). (A,D,G) show the choroids, retinas, and ciliary bodies infiltrated with CD20-positive primary CNS lymphoma cells (PCNSL+) (arrows). (A) shows CD44+ cells (chevron arrow), which are often located in capillaries near CD20-positive lymphoma cells. CD44+ cells were also seen in capillaries in the retina (D). Fewer CD44+ cells were found in the ciliary body. In the PCNSL negative (PCNSL-) group (B,E,H) and in the SCNSL group (C,F,I) no CD20+ and few CD44+ cells were found in the choroid, retina and ciliary body. ONL = outer nuclear layer, INL = inner nuclear layer, GCL = ganglion cell layer; scale bar 50 µm.