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. 2022 Sep 27;23(19):11400. doi: 10.3390/ijms231911400

Figure 4.

Figure 4

Applications of CRISPR-Cas13 system. (a). Cas13-driven biosensor for disease diagnosis. Cas13-based DNA and RNA detection methods and sample preparation steps are integrated into microfluidic biosensors for rapid pathogen detection; (b). Real-time nucleic acid imaging and tracking of living cells using type VI CRISPR systems. dCas13 proteins fused with fluorescent proteins (FPs) effector and coupling with specific guide RNA can be used for spatiotemporal visualization of the target RNA transcripts in living cells; (c). Antiviral application of type VI CRISPR systems. The type VI CRISPR systems target the genomic region of evolutionarily conserved ssRNA viruses to inhibit viral infection in human animals and plants; (d). CRISPR-Cas13 system-mediated genetic disease treatment.