Table 1.
Diagnostic performance of clinically used molecular biomarkers in the subset of studies cited in this article.
| Ref. | Systematic Review or Meta-Analysis | Sample Size | CA125 | HE4 | ROMA | RMI | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patients | Control | Se (%) (95% CI) | Sp (%) (95% CI) | PPV (%) | NPV (%) | AUC (95% CI) | Se (%) (95% CI) | Sp (%) (95% CI) | PPV (%) | NPV (%) | AUC (95% CI) | Se (%) (95% CI) | Sp (%) (95% CI) | PPV (%) | NPV (%) | AUC (95% CI) | Se (%) (95% CI) | Sp (%) (95% CI) | PPV (%) | NPV (%) | AUC (95% CI) | ||
| [16] | No | 91 | 182 | 0.77 | |||||||||||||||||||
| [20] | No | 57 | 271 | 90.8 | 67.1 | 35.8 | 97.3 | 56.9 | 96.9 | 78.7 | 91.8 | 89.2 | 87.3 | 58.6 | 97.6 | ||||||||
| [65] | No | 50 | 100 | 52 | 54 | 54 | 70 | 86 | 74 | 84 | 72 | 84 | |||||||||||
| [46] | No | 70 | 762 | 71.4 | 74.8 | 20.7 | 96.6 | 0.811 | 0.896 | ||||||||||||||
| [48] | Yes | 4549 | 8082 | 78 | 86 | ||||||||||||||||||
| [50] | No | 82 | 1147 | 80.5 | 92.2 | 0.927 | 90.2 | 75.6 | 0.927 | 87.8 | 80.8 | 0.959 | |||||||||||
| [65] | Yes | 2117 | 3837 | 90 | 91 | 90 | 93 | 0.96 | |||||||||||||||
| [66] | Yes | 84 | 73 | 0.86 | 73 | 90 | 0.91 | 86 | 79 | 0.91 | |||||||||||||
| [67] | No | 56 | 225 | 87.9 | 46.2 | 29.8 | 93.6 | 0.81 | 53.4 | 97.8 | 86.1 | 89 | 0.77 | 79.3 | 79.8 | 50.5 | 93.7 | 0.89 | 64 | 89.8 | 61 | 91 | |
| [69] | No | 31 | 115 | 83.9 | 83.5 | 57.8 | 95.1 | ||||||||||||||||
| [70] | No | 179 | 511 | 74.3 | 84.4 | 66.5 | 91.1 | ||||||||||||||||
| [90] | No | 157 | 110 | 71 | 88 | 90 | 68 | 0.88 | |||||||||||||||