Protein destruction by metal oxide nanomaterials. (a) Schematic illustration of preparation process and antibacterial mechanism of Fe2C@Fe3O4-PEG thermogenic nanozyme. (b) The activity of glutathione reductase (GR, left) and adenosine triphosphatases (right) after different treatments. *** indicate obvious differences at p < 0.001. (c) Scheme of copper clusters (CuCs) healing local MRSA skin wound infection. (d) Enzymatic activity of GR and reduced glutathione levels in MRSA and E. coli after treatment with CuCs. GSSG, glutathione disulfide; GSH, reduced glutathione; ROS, reactive oxygen species; NADPH, nicotinamide adenine dinucleotide phosphate.