Figure 1.

Summary of the main advantages of multicellularity and 3D architecture in modelling systems. Several features can be enhanced and boosted when co-culturing multiple cell types in 3D microenvironments. They include complex tissue architecture, the diffusion of paracrine soluble molecules, the establishment of cell-to-cell and cell–ECM interactions, and integrated mechanical sensing and responses. This figure was created with Biorender software.