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NGF exacerbates orofacial pain by upregulating the expression of CGRP in trigeminal neurons. (a,d) The effects of NGF and Anti NGF on the expression of CGRP in trigeminal ganglia in vivo (a) Immunofluorescence (×400). (b) Fluorescence in situ hybridization (×400). (c) Quantification of immunofluorescence. (d) Quantification of fluorescence in situ hybridization. (e) The effects of NGF and Anti NGF on orofacial pain (Data are presented as mean ± SD, n = 6. *: p < 0.05).
