Table 1.
Definition of the 4 molecular prognostic groups of endometrial carcinoma.
| Molecular Prognostic Group | Original Name | Identified by | Surrogate Marker |
|---|---|---|---|
| POLE-mutated | POLE/ultramutated | High mutational load (232 × 10−6 mutations per megabase) |
POLE exonuclease domain mutation |
| MMR-deficient | MSI/hypermutated | High mutational load (18 × 10−6 mutations per megabase) |
Loss of MMR proteins expression |
| p53-abnormal | Copy number—high/serous | Low mutational load; high copy-number variations |
Abnormal p53 expression |
| NSMP | Copy number—low/ endometrioid |
Low mutational load; low copy-number variations |
Absence of the other markers |