Figure 3.

Functional structure of the androgen receptor (AR). The diagram shows the two distinct parts of the protein chain, joined at a flexible joint (hinge). The longest arm contains the N-terminal domain, incorporating the AF1 (activation function 1) binding sites, as well as the DNA-binding domain and a short sequence (nuclear localization signal) needed for the nuclear transport of the AR. The shorter arm (C-terminal domain) contains the AF2 (activation function 2) binding site. This domain contains a key binding niche, the LBP (ligand-binding pocket), in the core of AF2.