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Strategies to target p53 aggregation as anticancer candidates. (A) Thiol alkylating agents targeting mutp53 cysteines. (B) Designed peptides that bind in a complementary way to regions of p53 with a greater propensity to aggregate. (C) Miscellaneous compounds with anti-protein aggregation properties previously tested in neurodegenerative diseases. (D) Compounds with metallochaperone- or molecular-chaperone-based mechanisms.
