Figure 2.

Aggrephagy mechanism described in p53-expressing cancer cells. Misfolded p53 and its aggresomes are recognized by autophagy receptors, such as p62, and are then directed to autophagic degradation. The autophagy process involves the formation and elongation of the phagophore membrane; engulfment of protein aggregates by the phagophore membrane to form autophagosomes; fusion of the autophagosome with lysosomes to form autophagolysosomes; and degradation of protein aggregates by proteolytic enzymes in lysosomes.